Risk model validation

Report on model validation in KARMA and GC-HBOC. The final BOADICEA model will be evaluated in two prospective cohort studies (KARMA and GC-HBOC). Sequencing data from the BRIDGES panel, together with data on the SNP polygenic risk score (PRS), lifestyle risk factors and breast density, will be obtained from ~1,500 cases and 1,500 matched controls. The model will be evaluated for calibration and discrimination, and compared with the existing BOADICEA model.