Demonstration prototype of EuroMix model toolbox (module priority setting).

In an early stage, ANSES will provide a method for identification of major mixtures in terms of exposure, based on the model developed in the PERICLES programme (Béchaux et al. 2013). DLO-B with the help of ANSES will implement a module to select the appropriate combinations of chemicals for mixture experiments of combined exposure to multiple food-related toxic substances, based on exposure patterns, possibly weighted by relative potency factors (Milestone 6.1, M6). The chemicals contributing most to the exposure will be identified, and will be the basis for mixture testing in WP3 and WP4. These models will be tested using data gathered in Task 5.1 (M7-9). DLO-B will provide a demonstration prototype of the EuroMix model toolbox to integrate exposure assessment of selected and unselected chemicals based on a ‘Retain and refine’ concept (Deliverable 6.1, M18).