Periodic Reporting for period 2 - X-PAND (Exploiting ex vivo expansion and deep multiomics profiling to bring novel, efficient and safer hematopoietic stem cell gene therapies to clinical application)

X-PAND aims to revolutionize hematopoietic stem cell (HSC) genetic engineering. The challenge is designing protocols for HSC culture that balance productive expansion with efficient genetic manipulation while preserving long-term repopulating potential. It seeks to develop a...