Application of the systemic operation factory in cascade 4

Using the systemic operations factory approach and the data obtained in Task 3.1., cascade 4 will be optimized. A computer-aided method based on the data bases and on the criteria will help to minimize the number of unit operations as well as the operating conditions for a particular target molecule in order to approach “One-Flow” operation. Just to give an example, matrixes may be built to check for orthogonality, the latter being assessed as a binary answer 0 or 1. The criteria for chemical orthogonality will be defined as 0 when, in a two reactions system, the yields of the expected products are > 99% and without degradation of the yield in solution for a time long enough to proceed with further workup. In any other situation, a non-orthogonal notation (1) is given. Minimizing the value of the matrixes will drive to (close to) One-Flow operations.