Cascade 4 - Synthesis of Capecitabine

At first the individual reaction steps will be studied and suitable catalysts will be identified by means of a screening of organo- and biocatalysts, respectively. Subsequently, process development for the desired key steps for the multi-step synthesis of the Capecitabine key intermediate will be done, followed by an experimental and theoretical study rationalizing the compatibility of the organocatalytic with the enzymatic reactions. Finally, the combination of the steps in a batch-process will be carried out to serve as the benchmark for the subsequent combination under flow.