5′ modifications to CRISPR–Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage

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Authors: Grace Mullally, Kara van Aelst, Mohsin M Naqvi, Fiona M Diffin, Tautvydas Karvelis, Giedrius Gasiunas, Virginijus Siksnys, Mark D Szczelkun

Journal title: Nucleic Acids Research

Journal number: 48/12

Journal publisher: Oxford University Press

Published year: 2020

Published pages: 6811-6823

DOI identifier: 10.1093/nar/gkaa477

ISSN: 0305-1048