Periodic Reporting for period 4 - BEAT (The functional interaction of EGFR and beta-catenin signalling in colorectal cancer: Genetics, mechanisms, and therapeutic potential.)

Monoclonal antibodies against the EGF receptor (EGFR) provide substantive benefit to patients with metastatic colorectal cancer (mCRC). However, no genetic lesions that robustly predict ‘addiction’ to the EGFR pathway have been yet identified. Further, even in tumours that...