Periodic Reporting for period 1 - CRISPR-KissCas9 (Challenging the KNDy Hypothesis Using CRISPR-Cas9 Genome Editing: Evaluation of the Role of Neurokinin B and Dynorphin in Kiss1 neurons in the Control of Fertility)

Alterations in fertility, e.g., in polycystic ovary syndrome (PCOS) and hypogonadism associated with metabolic disorders, are related to functional alterations in the neuronal networks that control the pulsatile gonadotropin-releasing hormone (GnRH) secretion. The function of...