Periodic Reporting for period 1 - DIAL-IN (Dynamic Integrated structural and proteomic Analysis of the LUBAC complex and its involvement in NF-κB and inflammation)

PROBLEM AND RELEVANCE: TNF-α is among the most critical molecules regulating the inflammatory response in mammalians. By binding to its cognate receptor, TNF-RI, the pleiotropic cytokine TNF-α induces the formation of a large multiprotein complex (the TNF-RSC - tumor...