ProteinConjugates-232378 New method for site-selective tryptophan modification

Summary

The method involvs the Pd-(II) catalyzed, norbornene-mediated C−H activation reaction for selective alkylation at the C-2 indole position of Trp and selective formation of Caryl-N bonds at Trp.

More information & hyperlinks

Web resources:

https://www.ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5b4460aeb&appId=PPGMS

Associated projects

ProteinConjugates - A training network for the chemical site-selective modification of proteins: Preparation of the next-generation of therapeutic chemically-defined protein conjugates

Organisations

Not specified