Periodic Reporting for period 1 - PI3K MODULATORS (Identification and characterisation of new class of PI3K modulators in oncology)

The phosphoinositide 3-kinase (PI3K) lipid kinases play a critical role in the regulation of many cellular functions including cell proliferation, survival and migration. The class IA PI3Ks are heterodimers of a p110 catalytic subunit (alpha, beta, delta) and a p85 regulatory...