Periodic Reporting for period 1 - CAR T-REX (CAR T cells Rewired to prevent EXhaustion in the tumour microenvironment)

Adoptively transferred T cells expressing recombinant chimeric antigen receptors (CAR T cells) have been approved for the treatment of several haematological malignancies. However, CAR T cell therapy for patients with solid tumours has shown limited benefit so far. One problem...