Thiol-Reactive or Redox-Active: Revising a Repurposing Screen Led to a New Invalidation Pipeline and Identified a True Noncovalent Inhibitor Against Papain-like Protease from SARS-CoV-2

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Authors: Maria Kuzikov, Stefano Morasso, Jeanette Reinshagen, Markus Wolf, Vittoria Monaco, Flora Cozzolino, Simona Golič Grdadolnik, Primož Šket, Janez Plavec, Daniela Iaconis, Vincenzo Summa, Angela Corona, Annalaura Paulis, Francesca Esposito, Enzo Tramontano, Maria Monti, Andrea R. Beccari, Candida Manelfi, Björn Windshügel, Philip Gribbon, Paola Storici, Andrea Zaliani

Journal title: ACS Pharmacology & Translational Science

Journal number: 8

Journal publisher: American Chemical Society (ACS)

Published year: 2025

DOI identifier: 10.1021/ACSPTSCI.4C00325

ISSN: 2575-9108