The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate

Summary

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Authors: Nina Weisshaar; Sicong Ma; Yanan Ming; Alaa Madi; Alessa Mieg; Marvin Hering; Ferdinand Zettl; Kerstin Mohr; Nora Ten Bosch; Diana Stichling; Michael Buettner; Gernot Poschet; Glynis Klinke; Michael Schulz; Nina Kunze-Rohrbach; Carolin Kerber; Isabel Madeleine Klein; Jingxia Wu; Xi Wang; Guoliang Cui

Journal title: Nature Immunology

Journal publisher: Nature Springer

Published year: 2023

DOI identifier: 10.1038/s41590-023-01636-5

ISSN: 1529-2916