Targeting <i>Plasmodium falciparum</i> IspD in the Methyl-<scp>d</scp>-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity

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Authors: Daan Willocx, Lorenzo Bizzarri, Alaa Alhayek, Deepika Kannan, Patricia Bravo, Boris Illarionov, Katharina Rox, Jonas Lohse, Markus Fischer, Andreas M. Kany, Hannes Hahne, Matthias Rottmann, Matthias Witschel, Audrey Odom John, Mostafa M. Hamed, Eleonora Diamanti, Anna K. H. Hirsch

Journal title: Journal of Medicinal Chemistry

Journal number: 67

Journal publisher: American Chemical Society

Published year: 2024

Published pages: 17070-17086

DOI identifier: 10.1021/acs.jmedchem.4c00212

ISSN: 0022-2623