Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?

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Authors: Daan W. van Valkengoed, Makoto Hirasawa, Vivi Rottschäfer, Elizabeth C. M. de Lange

Journal title: Journal of Pharmacokinetics and Pharmacodynamics

Journal number: 52

Journal publisher: Kluwer Academic/Plenum Publishers

Published year: 2025

DOI identifier: 10.1007/s10928-025-09963-w

ISSN: 1567-567X