A simulation study of the impact of drug-IKr binding mechanisms on biomarkers of proarrhythmic risk reveals a crucial role in reverse use-dependence of action potential duration and a marked influence on the vulnerable window

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Authors: Julio Gomis-Tena, Fernando Escobar, Lucia Romero

Journal title: Computer Methods and Programs in Biomedicine

Journal number: 260

Journal publisher: Elsevier BV

Published year: 2025

Published pages: 108566

DOI identifier: 10.1016/j.cmpb.2024.108566

ISSN: 0169-2607