Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

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Authors: Solvay, M; Holfelder, P; Klaessens, S; Pilotte, L; Stroobant, V; Lamy, J; Naulaerts, S; Spillier, Q; Frédérick, R; De Plaen, E; Sers, C; Opitz, CA; Van den Eynde, BJ; Zhu, J

Journal title: Journal for ImmunoTherapy of Cancer

Journal publisher: BMJ Publishing Group

Published year: 2023

DOI identifier: 10.1101/2023.01.16.524177

ISSN: 2051-1426