Periodic Reporting for period 1 - HUMANE (Window to the brain: a game changer in the discovery of human neuronal circuitry, cellular heterogenicity and biomarker profile indicative of early Alzheimer's disease -related pathology)

Alzheimer’s disease (AD) is the main cause of dementia and possesses a major socio-economic burden. Most AD cases are late onset and sporadic. Multiple animal studies have suggested that microglial dysfunctions contribute to AD progression and even underlie disease onset...