Periodic Reporting for period 1 - BiTE-CAR (CD22/CD19 dual redirection Dual targeting of CD22 and CD19 with BiTE-secreting and CAR-expressing bispecific T-cells for adoptive Cellular ImmunoTherapy in advanced B-cell Acute Lymphoblastic Leukemia)

Chimeric Antigen Receptor (CAR) T-cell therapy has revolutionized the treatment of B-cell acute leukemia (B-ALL), with several successful therapies targeting the CD19 protein on cancer cells. However, some leukemia cells can escape treatment by losing CD19, leading to...