Periodic Reporting for period 1 - PLURImet (Building a metabolic atlas of human pluripotency: dissecting the interplay between pluripotency and metabolism in human stem cells.)

The naive inner cell mass of the human embryo is characterised by unlimited developmental plasticity as it gives rise to all embryonic and extraembryonic lineages. This state can be recapitulated in vitro using naive human pluripotent stem cells (hPSCs), a new prominent tool...