The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease

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Authors: Kitty B. Murphy; Di Hu; Leen Wolfs; Susan K. Rohde; Gonzalo Leguía Fauró; Ivana Geric; Renzo Mancuso; Bart De Strooper; Sarah J. Marzi

Journal title: Nature Communications

Journal publisher: Springer Nature

Published year: 2025

DOI identifier: 10.1038/S41467-025-60099-4