Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release

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Authors: Niayesh Zarifi, Pooja Asthana, Hiva Doustmohammadi, Cindy Klaus, Janet Sanchez, Serena E. Hunt, Rojo V. Rakotoharisoa, Sílvia Osuna, James S. Fraser, Roberto A. Chica

Journal title: Nature Communications

Journal number: 16

Journal publisher: Springer Science and Business Media LLC

Published year: 2025

DOI identifier: 10.1038/S41467-025-63802-7

ISSN: 2041-1723